What is PRP IVF Application? Who is it applied to?

Plasma-rich plasma (PRP) is serum enriched with blood cells that provide clotting called platelets. These cells, which provide coagulation, contain the growth factors necessary for the repair of damaged tissues in the body and for their recovery. In the PRP serum, however, more and more cells are concentrated than platelets collected in damaged tissues.

In the PRP method, this miraculous serum is obtained after a small amount of the person’s own blood is taken through a special series of processes and injected into the person himself. This method is used in many fields of medicine and in the field of gynecology ovarian can be applied to the ovaries in women who have a decrease in their storage or who have an early diagnosis of menopause, and when the inner wall of the uterus is not thickened.

Rich Plasma History from Coagulation Cells

The use of plasma (PRP) rich in coagulation cells in medicine first started in the field of hematology, the specialty of blood diseases. Hematology specialists first introduced PRP application in 1970. Today, it is widely used in dentistry, jaw surgery, orthopedic surgeries, plastic surgery, skin burns or skin wounds and ovaries.

Is There A Place Of Rich Plasma From Coagulation Cells In Early Menopause?

The natural age of menopause is 49 years on average and varies between 45 and 53 years. Early menopause is defined as the onset of the menopausal process before the age of 40. An early diagnosis of menopause is made under the age of 40, with a rare condition of menstruation or menstrual delay that lasts for at least 4 months, and the FSH value of blood hormones is above 25 mIU / ml. When the complaints of the patients are evaluated, findings such as hot flashes, sleep disturbances, emotional sensitivity, vaginal dryness can be encountered. It also causes general health problems and serious problems in fertility.


What are the causes of early menopause?

In 6 of 10 patients diagnosed with early menopause, the cause is unknown. Among the causes that can be identified, the most common causes are familial causes; If the person has a history of early menopause in the mother, aunt or sisters, the risk of early menopause increases 4-9 times. Another reason is that the cells called antibodies against one’s own cells develop for an unknown reason and damage their own ovaries, resulting in a decrease in the ovarian reserve and accelerates the menopause process. Finally, there are genetic causes. In addition, cigarette smoking and excessive coffee consumption also cause rapid consumption of ovarian stores.

Treatment Options in Early Menopause

Depending on whether there is a desire for fertility after detailed information, either a hormone supplement or IVF can be applied. The probability of obtaining an egg with the egg-growing drugs used in IVF treatment is very low.

Was There A Place Of Rich Plasma From Coagulation Cells In Early Menopause r?

PRP serum containing more than 800 protein molecules, hormones and growth factors can be used in many areas of medicine as well as in the field of early menopause and ovaries as well as in the field of medicine, based on the discovery that it provides increased blood supply, cell migration, and proliferation of tissues. started to be used in patients with limited reserves. In the light of scientific evidence, the number of eggs increased after PRP treatment in the ovaries and an improvement in blood hormones has been reported. Afterwards, pregnancies were reported both spontaneously and after IVF treatment.

Is There A Place Of Rich Plasma From Coagulation Cells In Decreased Egg Reserve?

Today, due to the increase in the living conditions and the place of women in working life, postponing the age of childbearing to older ages leads to more encounters with patients with reduced ovarian reserve. Decreased egg reserves can be expressed as a woman of reproductive age having fewer egg sacs compared to other women in her age group. In 2011, the European Association for Reproductive Medicine identified a low ovarian response. According to this:

1- Candidates over a certain age (≥ 40 years old) or having medication, radiation therapy, ovarian surgery due to cancer constitute a risk factor for bad ovarian reserve.

2- Less than 3 eggs were obtained after previous IVF treatment

3- Decreased ovarian reserve test (The number of egg sacs examined in ultrasonography is below 5-7 and / or the blood reserve test in blood is at low values ​​(Anti Mülleryan Hormone <1.2 ng / mL)).

Why Does Ovarian Reserve Decrease?

Every woman is born with a certain number of eggs, and her egg heritage is gradually depleted over the years, and then the menopausal period begins. However, the rate of decrease has different acceleration in each patient. This can be explained in two different ways:

1- Less follicle heritage left in the womb

2- It can be explained by the rapid ovarian loss due to various reasons.

Patients who may have decreased risk of egg reserves;

  • Patients above the age of 35
  • Family history of early menopause
  • Previous ovarian or cyst surgeries,
  • Chocolate cysts
  • Cancer-related drug or radiation therapy history
  • Harmful habits such as smoking and alcohol
  • Woman is overweight
  • Presence of some genetic diseases such as fragile X syndrome, mosaic turner syndrome.


Who can apply the PRP IVF procedure?

Plasma-rich plasma (PRP), although it is a very recent application, is a promising application for women with decreased ovarian reserve and early menopause. Although scientific research on this subject is limited, positive results have been reported after PRP application.

When Can Rich Plasma Process be Performed from Coagulation Cells?

PRP application can be applied at any time after menstrual period in couples planned to treat Plasma Rich Plasma (PRP) from coagulation cells.

How to Apply Rich Plasma Process from Coagulation Cells?

Approximately 20 ml of blood is collected from the coagulation cells (PRP) treatment, and after the centrifugation (separation of liquid and solid substances) in a special tube, the serum part that dissolves is applied to the ovaries under general anesthesia on the same day. The processing time can vary from approximately 15-30 minutes. After the procedure, the patient is discharged on the same day after being followed up in the recovery room for 30-60 minutes and making sure everything is in order. A 2-6 month period is required for the application to take effect. Periodically, changes in the ovaries are checked by ultrasonography and blood tests. PRP application can be repeated every 4-6 months.

What are the Possible Risks of Rich Plasma Process from Coagulation Cells?

Information on risks is very limited, as coagulation-rich plasma (PRP) therapy and injection into the ovaries is still a new method. Since the serum rich in blood cells called platelets are separated and given to the same person again, it is defined as an autotransfusion and the risk of allergic reaction is considered to be minimum. Risks related to the PRP procedure include bleeding from the injection site or vaginal veins, infection, and adjacent organ injury.

What should be considered before and after Rich Plasma Application from Coagulation Cells?

Points to Consider Before Treatment

  • At least 8 hours of fasting period before treatment
  • Alcoholic beverages not used before treatment
  • It is necessary to discontinue ginkgo biloba (temple tree), blood-thinning drugs, green tea, aspirin and non-steroidal anti-inflammatory (rheumatic) drugs at least 3 days in advance.

Considerations After Treatment

  • PRP After the procedure, our patients can leave our hospital for 30-60 minutes after rest.
  • We recommend being at home for 1 day at rest after the PRP procedure.
  • 1 day after the PRP procedure, bathing can be done with warm water and standing shower.
  • Sexual prohibition continues for 7 days.
  • Activities such as sports and heavy work should be avoided, but daily work can be done that will not tire our patients.
  • After the PRP procedure, daily feeding can be continued. In order to avoid being constipated, it would be beneficial to stay away from fatty and spicy foods and to prefer easy-to-digest foods such as soups and fiber vegetables and fruits.

What will be the follow-up after Rich Plasma Application from Coagulation Cells?

Follow-up After PRP:

  • PRP We recommend menstrual correction to women who have not had any menstruation after the procedure.
  • The first control is usually in the second period, but in some cases, it may be recommended in the first period.
  • Control time is usually between the second and fourth days of menstruation.
  • The primary control method is to evaluate the ovaries ultrasonographically and to see whether or not the egg sacs are monitored in our women who have not previously had an egg sac (follicle).
  • In some cases, blood hormone levels can also be evaluated simultaneously.
  • If no clear response is observed in the controls, re-examination may be recommended in the following menstrual periods.


How many times can a rich plasma process be performed from coagulation cells?

Plasma-Rich Plasma (PRP) treatment from coagulation cells can be repeated at 6-month intervals, provided that there are no changes in the egg sacs (follicle), although 6 periods have passed in their subsequent controls.

Is It Possible To Take Advantage Of Rich Plasma Process From Coagulation Cells? How do we decide if we do not benefit?

In our women who have never had follicles before their control after the application of Rich Plasma Cells (PRP) from the coagulation cells, if your egg sacs (follicles) have not been observed, you can be considered as not benefiting from the PRP procedure. The fact that there is no significant increase in the number of egg sac (follicle) in follow-up after PRP in patients with a tendency to decrease in egg stores is not defined as not being beneficial directly, because we think that PRP may have a healing effect in egg quality as well as an increase in the number of follicles.

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