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What is Urobilinogen? Urobilinogen Elevation in Urine

What is Urobilinogen? Urobilinogen Elevation in Urine

What Does Urobilinogen Mean?

Urobilinogen; is a compound present in the urine. Urobilinogen amount in urine can be measured by urinalysis. Urobilinogen; It is formed by the destruction of bilirubin. Bilirubin is a yellowish compound that helps break down red blood cells in the livers. Normally, there is a small amount of urine in the urine, but this amount is small. If urine is too little urinary or at least, this indicates that the liver is not functioning properly. The high amount of urodrigine in urine may be an indication of liver diseases such as hepatitis and cirrhosis.

Why Do I Have to Test Urobilinogen in Urine?

Urobilinogen testing is part of a urinalysis, a test that measures different cells, chemicals and other substances in the urine. Urine analysis is usually part of the routine examination.

Doctor; When the patient sees a symptom of liver disease, they can conduct urodynamic tests as part of routine tests to monitor liver disease. These symptoms are:

  1. Jaundice (skin or eye)
  2. Nausea or vomiting
  3. Dark urine
  4. Abdominal pain and swelling
  5. Itching on the skin

Normal Urobilinogen Level in Urine

The normal urodynamic level in urine is less than 17 umol / L (<1 mg / dl). However, it is normal that the values ​​range from 0 to 8 mg / dl. Above or below this range, a urodynamic level is considered abnormal in a clinical setting.

Increased urobilinogen levels may be due to excessive RBC (red blood cell) destruction, overload of the liver, hematoma, intoxication and even liver cirrhosis.

Decrease in urodynamic levels may indicate a blockage in the bile duct system or bile production.

What are the Causes of Urobilinogen in Urine?


Hemolysis is the destruction of red blood cells before their normal life ends. Red blood cells normally live between 110 and 120 days. After this time they are naturally disintegrated and are mostly removed from the circulation by the spleen.

Some diseases or processes may cause red blood cells to be destroyed early. This requires the bone marrow to produce more than normal red blood cells. The balance between red blood cell destruction and production determines how low the red blood cell level is.

Causes of hemolysis: immune diseases, infections, drug side effects and intoxications.

Pernicious Anemia

Folic acid and vitamin B12 are necessary for the production of red blood cells. Inadequate of any of these two components in the body; it causes pernicious anemia (a condition where there is not enough red blood cells in the body) An insufficient amount of B12 causes destruction of red blood cells in the bone marrow and indirectly increases bilirubin production.

Liver Diseases

It is the main organ involved in many metabolic processes including the processing of liver bilirubin. When the liver is not working enough; bilirubin accumulation and as a result, urobilinogen accumulates. There are many diseases that affect the liver: hepatitis, cirrhosis and lung cancer.

Dubin-Johnson Syndrome

Dubin-Johnson syndrome is a rare hereditary disease that causes an increase in the amount of bilirubin. When the liver of these individuals is examined, the liver appears black due to the accumulation of a melanin-like pigment.

Congestive Heart Failure

It is a condition where the heart cannot pump as much blood as it needs to provide adequate perfusion. Urobilinogen is present in the urine.

Other causes of urobinogen in urine:

  1. Lead poisoning
  2. Cholestasis and bile duct obstruction
  3. Crigler-Najjar syndrome
  4. Side effects of some drugs
  5. Rotor syndrome

What does the Urobilinogen Test Results in Urine Mean?

If the test results indicate that the level of urodynamics in the urine is too low, not at all, or the test is negative, it may indicate:

  1. A blockage in the structures carrying bile from the liver
  2. A blockage in the blood flow of the liver
  3. A problem in liver function

If your test results are positive (higher than normal), this may indicate:

  1. Hepatitis
  2. Cirrhosis
  3. Drug-induced liver damage

Hemolytic anemia is a condition in which red blood cells are destroyed before they are replaced with new ones. This causes the body not to have sufficient red blood cells.

How to Lower the High Urobilinogen Level in Urine?

  1. Eat plenty of fruits and vegetables: a healthy diet with fruits and vegetables ; It is useful for balancing liver health and urodynamic levels. Red vegetables and fruits contain compounds that lower bilirubin levels to help lower urobilinogen levels. The tomato food is wonderful about it.
  2. Add fiber and healthy cereals to your diet: fiber; can help keep the liver healthy. Fruit and vegetables in addition to fiber; It is found in healthy whole grains, rice and nuts. 25 grams of fiber per day for men; and 35 grams in women.
  3. Avoid processed foods: Unhealthy nutrition can disrupt liver function, and may cause bilirubin and urobilinogen levels to rise. Most follow a diet filled with fresh, unprocessed and natural foods. Avoid refined sugar, refined carbohydrates, fast food, fried foods, prepackaged and processed foods.
  4. For plenty of water: The only easy way to help keep urodynamic levels at normal levels is to take plenty of fluid into the body. Drink at least 8 glasses of water daily.


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